Curriculum Vitae

Diane Newell obtained membership of the Institute of Biology qualifications (BSc (Hons) equivalent) in Biochemistry and Biophysics from North East Surrey College of Technology in 1973 while working for the scientific Civil Service firstly at Porton Down, Salisbury on the immunochemistry of lectins and then at the Central Veterinary Laboratory, Weybridge on sheep parasites.

 

While working for the British American Tobacco company on in vitro assays of toxicity and carcinogenicity she developed an expertise in cell and organ culture leading to several patent applications. Diane then joined the Haematology Department at the University of Southampton Medical School and completed her PhD on the Surface and Fine Structure of Lymphocytes from in 1976 gaining considerable skills in aspects of electron microscopy and histopathology leading to several grant awards from the private funding bodies such as the Leukaemia Research Council.

 

In 1979 she was appointed as a Principal Grade Microbiologist to the Public Health Laboratory Service based at Southampton General Hospital and later seconded to the Centre for Applied Microbiology and Research at Porton Down as a Grade A Scientist. Within the PHLS Diane developed skills and expertise in the pathogenicity, immunology, detection and control of a variety of human bacterial and viral pathogens including campylobacters, helicobacters and herpes virus.

 

In 1991 Diane was recruited by the Veterinary Laboratories Agency as a senior scientific consultant to managed research on various zoonotic agents including mycobacteria, campylobacters, salmonellae and yersinia. 

 

Diane has had over 30 years of research management experience, managing focussed groups of up to 35 scientists. In 1991 she was awarded a bursary to the Ashridge Management College and received the General Management Diploma. These management skills were key to the development and co-ordination of several European projects. In particular Diane initiated, designed, planned, implemented and directed the EU-funded Network of Excellence Med-Vet-Net. This network co-ordinated the research on zoonotic diseases of over 350 scientists from 16 institutes in  10 countries.

 

In September 2008 Diane established Food-borne Zoonoses Consultancy.

 

In June 2009 Diane was awarded an OBE for services to science.

 

Membership of Professional Bodies

Member of the British Society for Immunology

Member of the Society for Microbiology

Member of the American Society for Microbiology

Fellow of Royal Society of Medicine

Veterinary Research Club

 Association of Veterinary Teaching and Research Work

Chartered Member and Fellow of the Institute of Biology

 

Honours and Awards

1987     British Society of Gastorenterology, Golden Jubilee Prize

1992     F C Donders Chair, Faculty of Veterinary Medicine, Uni. Of Utrecht

1997-2000  Visiting Professor, Royal Veterinary College, London

1997     Visiting Senior Lecturer, University of Cape Town

1998      British Council Fellowship, Australia

2000-now Visiting Professor, Faculty Veterinary Medicine, Uni. of Bristol

2000-2004 National Council, Ass. of Veterinary Teaching and Research Work

2001- now Fellow of the Institute of Biology

2001- now Editorial Board of Applied and Environmental Microbiology

2003- 2006 National Council, Society for Applied Microbiology

Publications

1.      Newell DG, McBride H and Pearson AD (1983)  The idenification of outer membrane proteins and flagella of Campylobacter jejuni. J Gen Microbiol, 130, 1201-1208

2.      Newell DG, McBride H, Sanders F, Dehele Y and Pearson AD (1984) The virulence of clinical and environmental isolates of Campylobacter jejuni. J Hygiene, 94, 45-54

3.      Steer H and Newell DG (1985) Immunological identification of Campylobacter pyloridis in gastric biopsy tissue. Lancet, ii, 38

4.      Newell DG, McBride H and Dolby J (1985) Investigations of the role of flagella in the colonisation of infant mice with Campylobacter jejuni and attachment of Campylobacter jejuni to human intestinal epithelial cell lines. J Hygiene, 95, 217-227

5.      Wenman WM, Chai J, Louie TJ, Goudreau C, Lior H, Newell DG, Pearson AD and Taylor DE (1985) Antigenic analysis of Campylobacter flagella and other proteins. J Clin Microbiol, 21, 108-112

6.      Dolby JM and Newell DG (1986) Protection against colonisation by Campylobacter jejuni of infant mice form mothers vaccinated with flagellated and non-flagellated C.jejuni vaccines. J Hygiene, 96, 143-151

7.      Newell DG (1986) Monoclonal antibodies directed against the flagella of Campylobacter jejuni : Production, characterisation and lack of effect on the colonisation of infant mice. J Hygiene, 96, 131-141

8.      Newell DG (1986) Monoclonal antibodies directed against the flagella of Campylobacter jejuni : Serotypic and cross-reacting specificity and potential use in diagnosis. J Hygiene, 96, 377-384

9.      Newell DG (1986) Identification of the outer membrane proteins of Campylobacter pyloridis and antigenic cross-reactivity between Campylobacter pyloridis and Campylobacter jejuni. J Gen Microbiol, 133, 163-170

10.   Blaser MJ, Hopkins JA, Perez-Perez GI, Cody HJ and Newell DG (1986) Antigenicity of Campylobacter jejuni flagella. Infect Immun, 53, 47-52

11.   Steer MW, Hawtin PR and Newell DG (1987) An ELISA technique for the serodiagnosis of Campylobacter pyloridis infection in patients with gastritis and benign duodenal ulceration. Serodiagn Immunother, 1, 253-259

12.   Newell DG (1987) Human serum antibody responses to the surface protein antigens of Campylobacter pyloridis. Serodiagn Immunther, 1, 209-217

13.   Quintero GA, Williams JD, Wingate DL and Newell DG (1988) A microbiological aetiology for gastritis and peptic ulceration. World J Surgery, 12, 718-722

14.   Newell DG, Hudson MJ and Baskerville A (1987) Natually occuring gastritis associated with Campylobacter pylori infection in the rhesus monkey. Lancet, ii, 1338

 

15.   Newell DG, Johnston BJ, Ali MH and Reed PI (1987) An enzyme-linked immunsorbent assay for the serodiagnosis of Campylobacter pylori- associated gastritis. Scand J Gastroenterol. 23 (suppl 142), 53-57

16.   Baskerville A and Newell DG (1987) Naturally occuring chronic gastritis and Campylobacter pylori infection in the rhesus monkey : A potential model for gastritis in man. Gut, 29, 465-472

17.   McBride BW, Ridgeway P, Philpotts R and Newell DG (1987) Mucosal antibody response to vaginal infection with herpes simplex virus in pre-vaccinated guinea pigs. Vaccine, 6, 414-419

18.   Newell DG, Hudson MJ and Baskerville A (1987) The isolation of a gastric campylobacter-like organism, from the stomach of four rhesus monkeys, and identification as Campylobacter pylori. J Med Microbiol, 27, 41-44

19.   Newton CM, Newell DG, Wood M and Baskerville M (1988) Campylobacter infection in a closed dog colony. Vet Rec, 123, 152-154

20.   McBride BW and Newell DG (1989) Production and characterisation of monoclonal antibodies directed against guinea pig IgG subclasses. J Immunol Methods, 118, 193-198

21.   Newell DG and Stacey AR (1989) Antigens for the serodiagnosis of Campylobacter pylori infections. Gastroenterologie Clinique et Biologique, 13, 37-41

22.   McBride BW, Ridgeway P, Philpotts R and Newell DG (1989) Systemic and mucosal cell mediated immune responses against herpes simplex virus in vaccinated guinea pigs detected by lymphocyte proliferation and monoclonal antibodies against macrophages and T cells. Vaccine, 6, 414-418

23.   Newell DG and Rathbone BJ (1989)  The serodiagnosis of Campylobacter pylori infection. Serodiagn Immunother., 3, 1-6

24.   Newell DG, Lee A, Hawtin PR, Hudson MJ, Stacey AR and Fox J (1989) Antigenic conservation of the ureases of spiral and helical shaped bacteria colonising the stomachs

25.   of man and animals. FEMS Microbiol Letts, 65, 183-186

26.   Tolia V, Chang CH, Brennan S, Newell DG and Thirumoorthi MC (1990) Occurrance and diagnosis of Campylobacter pylori infection in children. Int Pediatr, 5, 37-41

27.   Dubois A, Tarnawski A, Newell DG, Fiala N, Dabros W, Stachura J, Krivan H, Heman-Ackah LM (1991) Gastric injury and invasion of parital cells by spiral bacteria in rhesus monkeys. Gastroenterol, 100, 884-891

28.   Hawtin PR, Stacey AR and Newell DG (1990) Investigation of the structure and localization of Helicobacter pylori urease with monoclonal antibodies. J Gen Microbiol, 136, 1995-2000

29.   Stacey AR, Hawtin PR and Newell DG (1990) The antigenicity of fractions of Helicobacter pylori prepared by fast protein liquid chromatography and urease captured by monoclonal antibodies. Eur J Clin Micobiol Inf Dis, 9, 732-737

30.   Talley NJ, Newell DG, Ormand JE, Carpenter HA, Wilson WR, Zinsmeister AR, Perez-Perez GI and Blaser MJ (1991) Serodiagnosis of Helicobacter pylori : A comparison of enzyme-linked immunosorbent assays. J Clin Microbiol, 29, 1635-9

31.   Newell DG (1991) Virulence factors of Helicobacter pylori. Scand J Gastroenterol. 26, suppl 187, 31-8

32.   Newell DG, Hawtin PR, Stacey AR, MacDougall MH and Ruddle AC (1991) Estimation of prevalence of Helicobacter pylori infection in an elderly asymptomatic population comparing [14C] urea breath test and serology. J Clin Pathol, 44 , 385-387

33.   King V, Wassenaar T, van der Zeijst BAM and Newell DG (1991) Variations in Campylobacter jejuni flagellin and flagellin genes during in vivo and in vitro passage. Micro Ecol Health Dis, 4, 135-140

34.   Nuijten PJM, van der Zeijst and Newell DG (1991) Localization of immunogenic regions on the flagellin proteins of Campylobacter jejuni 81116. Infect Immun, 59, 1100-1105

35.   Forman D, Newell DG, Fullerton F, Yarnell JWG, Stacey AR, Wald N and Sitas F (1991) An association between Helicobacter pylori infection and the risk of gastric cancer : Evidence from a prospective investigation. Brit Med J, 302, 1302-05

 

36.   Forman, Sitas F, Newell DG, Stacey AR, Boreham J, Peto R, Campbell TC, Li J, Chen J (1990) Geographic association of Helicobacter pylori antibody prevalence and gastric cancer  motality in rural China. Int J Cancer, 46, 608-611

37.   Hawtin PR, Delves HT, and Newell DG (1991) The demonstration of nickel in the urease of Helicobacter pylori by atomic absorption spectroscopy. FEMS Microbiol Letts, 77, 51-54

38.   Webberley MJ, Webberley JM, Newell DG, Lowe P and Melikian V (1992) Seroepidemiology of Helicobacter pylori infection in vegans and meat eaters. Epidemiology and Infection, 108. 457-462

39.   Logan RPH, Ploson RJ, Misiewicz JJ, Roa G, Karim NQ, Newell DG, Johnson P, Wadsworth J, Walker MM and Baroin JH (1991). Simplified single sample 13 Carbon urea breath test for Helicobacter pylori: comparison with histology, culture and ELISA serology. Gut, 32, 1461-64

40.   Newell DG, and Nachamkin I (1992) Immune responses directed against Campylobacter jejuni. In: Campylobacter jejuni; current status. (eds Nachamkin, Blaser and Tomkins) ASM press, pp 201-206

41.   Wassenaar TM, van der Zeijst B A M , Ayling R and Newell DG (1993) Colonisation of chicks by motility mutants of Campylobacter jejuni demonstrates the importance of flagellin A expression. J Gen Microbiol, 139, 1171-1175

42.   Nuijten PJM, Wassenaar TM, Newell DG and van der Zeijst BAM (1992) Molecular characterisation and analysis of Campylobacter jejuni flagellin genes and proteins. In: Campylobacter jejuni; current status. (eds Nachamkin, Blaser and Tomkins.) ASM press, pp 282-296

43.   Newell DG and Stacey AR (1992) The serology of Helicobacter pylori infections. In: Helicobacter pylori and gastroduodenal disease (eds Rathbone and Heatley) Blackwells Scientific Publications, Oxford, pp 64-73

44.   Sitas F, Smallwood R, Jewell D, Millard PR, Newell DG, Meuwissen SGM, Moses S, Zwiers A and Forman D (1993) Serum anti-Helicobacter pylori IgG antibodies and Pepsinogens A and C as serological markers of chronic atrophic gastritis. Cancer Epidemiology, Biomarkers and Prevention, 2, 119-123

45.   Wassenaar TM, Newell DG, Bleumink-Pluym NMC, Nuijten PJM and van der Zeijst BAM (1994) Differential flagellin expression in a flaA flaB+ mutant of Campylobacter jejuni. Infect Immunity, 62, 3901-6

46.   The EUROGAST Study Group (1993) Association between Helicobacter pylori infection and gastric cancer : An international study. Lancet, 341, 1359-1362

47.   The EUROGAST Study Group (1993) Epidemiology of and risk factors for Helicobacter pylori infection amoung 3194 persons in 17 populations. Gut, 34, 1672-1676

48.   Webb PM, Knight T, Greaves S, Wilson A, Newell DG, Elder J, Forman D (1993) Relationship between Helicobacter pylori infection and living conditions in childhood : Evidence for person to person transmission in early life. Brit Med J, 308, 750-753

49.   Newell DG and Stacey AR (1993) Serology In : Helicobacter pylori infection. (eds TC Northfield, M Mendall and PM Logan) Kluwer, Lancaster, pp 139-148

50.   Goodger J, Russell WP, Nolan A and Newell DG (1994) Production and characterisation of a monoclonal badger anti-immunoglobulin G and its use in defining the specificty of Mycobacterium bovis infection in badgers by western blot. Vet Immunol Immunopathol, 40, 243-252

51.   Goodger J, Nolan A, Russell WP, Dalley DJ, Thorns CJ, Stuart FA, Croston P and Newell DG (1994) The serodiagnosis of Mycobacterium bovis infection in badgers: The development of an indirect ELISA using a 25KDa antigen. Vet Rec, 135, 82-85

52.   Cawthraw S, Ayling R and Newell DG (1994) The isotype, speicificity and kinetics of systemic and mucosal antibodies to Campylobacter jejuni during experimental oral infections of chickens. Avian Dis, 38, 341-349

53.  Newell DG and Hewinson G (1995) Control of bovine tuberculosis by vaccination. Vet Rec 136 459-463

54.  Koenraad PMFJ, Ayling R, Hazeleger WC, Rombouts FM and Newell DG (1995) The speciation and subtyping of Campylobacter isolates from sewage plants and waste water from a connected poultry abattoir using molecular techniques. Epidemiol Infect, 115, 485-494

55.   Cawthraw SA., Wassenaar TM., Ayling R and Newell DG (1996) Increased colonization potential of Campylobacter jejuni strain 81116 after passage through chickens and its implication on the rate of transmission within flocks. Epidemiol Infect, 117, 213-215

56.   Ayling RD, Woodward MJ, Evans S and Newell DG (1995) A combined PCR/RFLP technique applied to the differentiation of poultry campylobacters for epidemiological investigations. Vet Res Sci, 60, 168-172

57.   The EUROGAST Study Group (1994) The epidemiology of low serum  pepsinogenA levels and an international association with gastric cancer rates. Gastroenterology, 107, 1335-1344

58.   Knight T, Wyatt J., Wilson A., Greaves S., Newell DG., Hengels K., Corlett M., Webb P., Forman D. and Elder J (1996) Helicobacter pylori, gastritis and serum pepsinogen levels in a non-patient population; development of a biomarker strategy for gastric atrophy in high risk groups. Brit J Cancer,  73, 819-824

59.  Webb P, Hengels KJ, Moller H, Newell DG, Palli D, Elder JB, Coleman MP, DeBacker G and Forman D. (1994) Epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. Gastroenterol, 107, 1335-1344

60.   Webb P M, Knight T, Newell  D G , Elder J B and Forman D (1996) Helicobacter pylori transmission: evidence from a comparison with hepatitis A virus. European J Gastroenterol Hepatol, 8, 439-441

61.   Filipe MI, Newell DG, Johnstone BJ, Caygill C and Reed P (1995) Helicobacter pylori in patients with intestinal metaplasia and in controls: a serological and biopsy study in four UK centres. European J Cancer Prevention, 4, 175-180

62.   Webb P.M.,. Yu MC, Forman D., Hendersen B.E., Newell D.G., Yuan Y-T, Gao Y.T., Ross RK., (1996) An apparent lack of association between Helicobacter pylori infection and risk of cancer in China. Int J Cancer., 67, 603-607

63.   Newell D.G. (1997) Campylobacters, Helicobacters and related organisms - disease associations in pigs. Pig J. 63-73

64.   Webb PM., Knight T, Elder JB, Newell DG and Forman D (1996) Is Helicobacter pylori transmitted from cats to humans? Helicobacter, 1, 79-81

65.   Newell D.G., Clifton-Hadley R., Cheeseman C (1997) The kinetics of serum antibody responses to natural infections with Mycobacterium bovis in one badger social group. Epidemiol. Infect., 118, 173-180

66.   Knight T., Greaves S., Wilson A., Hengles K., Newell D., Corlett M., Webb P., Forman D. and Elder J (1995) Variability in serum pepsinogen levels in an aysmptomatic population. Eur J Gastro Hepatol., 7, 647-654

67.   Beveridge TJ et al., (1997) Functions of S-layers. FEMS Microbiology Reviews, 20, 99-149

68.   Wassenaar TM., Geilhausen B and Newell DG (1998) Evidence of genomic instability in Campylobacter jejuni isolated from poultry meat. Appl Environ Microbiology. 64, 1816-1821

69.   Newell DG., Frost JA., Duim B., Wagenaar JA., Madden R., van der Plas J and On SLW (2000) New developments in the subtyping of Campylobacters. In: Campylobacter., I Nachamkin and MJ Blaser  (eds) . ASM Press, Washington, 27-44

70.   Bras AM., Chatterjee S., Wren BW, Newell DG and Ketley JM (1999) A novel Campylobacter jejuni two componenet regulatory system important for temperature-dependant growth and colonisation. J Bacteriol., J Bacteriol., 181, 3298-3302

71.   Newell DG and Wagenaar JA (2000) Poultry infections and their control. In : Campylobacters., I Nachamkin and MJ Blaser  (eds) . ASM Press, Washington, 497-510

72.   Wassenaar TM and Newell DG (2000) The genotyping of Campylobacter spp.  Applied and Environmental Microbiol., 66, 1-9

73.   Purdy D, Cawthraw S, Dickinson JH, Newell DG, and Park SF (1999) Generation of a superoxide dimutase (SOD)-deficient mutant of Campylobacter coli : evidence for the significance of SOD in campylobacter colonization. Applied and Environmental  Microbiology,  65, 2540-2546

74.   Grogono-Thomas R., Dworkin J., Blaser M J and Newell DG (2000) The role of the surface layer proteins of Campylobacter fetus subspecies fetus in ovine abortion. Infection and Immunity. 68, 1687-1691

75.   Fry BN, Feng S, Chen YY, Newell DG, Coloe PJ and Korolik V (2000)  The galE gene of Campylobacter jejuni is involved in lipopolysaccharide synthesis and virulence. Infection and Immunity, 68 2594-2601

76.   Newell DG (2001) Animal models of Campylobacter jejuni colonisation and disease and the lessons to be learned from similar Helicobacter pylori models. J Appl Microbiol, 90, 57S-67S

77.   Cawthraw S, Lind L, Kaijser B and Newell DG (2000) Antibodies directed against Campylobacter jejuni antigens in sera from poultry abattoir workers. Clin Exp Immunol, 122, 55-60

78.   Shreeve, JE., Toszeghy M., Pattison M and Newell DG (2000)  Sequential spread of Campylobacter infection in a multi-pen broiler house Avian Dis 44: 983-8

79.   Gavier-Widen D, Chambers MA, Palmer N, Newell DG and Hewinson RG (2001) The pathology of natural Mycobacterium bovis infection in European badgers (Meles meles) and its relationship to bacterial excretion. Vet Rec. 299-304

80.   Camarda A., Newell D.G., Nasti R., and Di Modugno G. (2000) Genotyping Campylobacter jejuni strains isolated from the gut and oviduct of laying hens. Avian Dis 44:907-12

81.   Ray, K., Zheng-Chao T., Grogono-Thomas R., Newell D.G., Thompson S.A. and Blaser M.J. (2000) Campylobacter fetus inversion occurs in the absence of Rec A function. Infection and Immunity,  68, 5663-5667

82.   Newell, DG., Duim B, vcan Bergen MAP, Grogono-Thomas, R., and Wagenaar JA (2000) Speciation, subspeciation and subtyping of Campylobacter species associated with bovine infertility and abortion.  Cattle Practice, 8, 421-425

83.   Wassenaar TM and Newell DG (2000) The genera Campylobacter. Online: The Prokaryotes (ed Dworkin M., Falkow.S., Rosenberg E., Schleifer KH., Stackerbrandt E)  http://link.springer-ny.com/link/service/books/10125/

84.   Wagenaar JA, van Bergen MAP, D G Newell, R Gregono-Thomas and B Duim (2001) Comparative Study Using Amplified Fragment Length Polymorphism Fingerprinting, PCR Genotyping, and Phenotyping To Differentiate Campylobacter fetus Strains Isolated from Animals. J Clin Microbiol. 2001 J39(6):2283-6.

85.   G. Manning, B. Duim, T. Wassenaar, J.A. Wagenaar, A. Ridley  and D.G. Newell. (2001)  Evidence for a genetically stable strain of Campylobacter jejuni. Applied and Environmental Microbiology. 67, 1185-89

86.   Newell DG., Shreeve J., Toszeghy M., Domingue G., Bull S., Humphrey T amd Mead G (2001) Changes in the carriage of Campylobacter strains by poultry carcasses during abattoir processing. Applied Environmental Microbiology, 67, 2636-2640.

87.   L. Petersen and D.G. Newell  (2001) The ability of Fla -typing schemes to discriminate between strains of Campylobacter jejuni J Appl Microbiol 91, 217-224

88.   Shi Y, Li J, Li M, Wang L, Guo W, Qin D, Geng C, Forman D, Newell DG, Peto R, Blot WJ (1997) Association of Helicobacter pylori infection with precancerous lesions and stomach cancer: a case-control study in Yangzhong County..Chin Med Sci J Sep;12(3):175-80

89.   Hartnett E., L. Kelly, D. Newell, M. Wooldridge, G. Gettinby (2001) A quantitative risk assessment for the occurrence of campylobacter in chickens at the point of slaughter. Epidem. Infect. 127, 195-206

90.   Chambers M.A., Stagg D.,  Gavier-Widen D., Lowrie D.,  Newell DG. And Hewinson RG (2001) A DNA vaccine encoding MPB83 from Mycobacterium bovis reduces M  bovis dissemination to the kidneys of mcue and is expressed in primary cell cultures of the European badger (Meles meles) Res Vet Sci, 71, 119-126

91.   Ahmed IH, Manning., Wassenaar TM and Newell DG (2002) Identification of genetic differences between two Campylobacter jejuni strains with different colonisation potentials. Microbiology 148, 1203-12

 

92.   D G Newell and H Davison  (2003) Campylobacter prevention and control. In Current topics in Food Safety in Animal Agriculture (ed Torrence ME and Isaccson R) Iowa Press, 211-220

 

93.   Shreeve JE., Toseghy M, Ridely A and Newell DG (2002) The carry-over of Campylobacter isolates between sequential poultry flocks. Avian Dis 46, 378-385

94.   Wassenaar TM, Wagenaar JA, Rigter A, Fearnley C, Newell DG and Duim B (2002) Homonucleotide stretches in chromosomal DNA of  Campylobacter jejuni display high frequency polymorphism as detected by direct PCR analysis. FEMS Microbiol Letts 212 77-85

95.   Cawthraw SA, Feldman RA, Sayers AR and Newell DG (2002) Long-term antibody responses following infection with Campyloabcter jejuni. Clin Exp Immunol 130:101-6

 

96.   Grogono-Thomas R., Blaser M.J., Ahmadi M. and Newell D.G. (2003) The role of S-layer protein antigenic diversity in the immune responses of sheep experimentally challenged with Campylobacter fetus subsp. fetus. Infect Immun 71, 147-154

97.   Newell DG (2002) The ecology of Campylobacter jejuni in avian and human hosts and the environment. Int J Infect Dis, 6, 3516-3521

98.   Newell DG and Fearnley C (2003) Sources of Campylobacter colonization in broiler chickens. Appl Environ Microbiol. 69, 4343-4351

99.   Randall, LP., Ridley AM., Cooles SW., Sharma M., Sayers AR., Pumbwe L., Newell DG., Piddock LJV., Woodwards MJ (2003) Prevalence of multiple antibiotic resistance in 443 Campylobacter spp. Isolated  from humans and animals. J Antimicro Chemother 52, 507-510

100.          Manning G., Dowson CG., Bagnell, MC., Ahmed, IH., West M and Newell D.G (2003) Multilocus sequence typing for conmparion of veterinary and human isolates of Campylobacter jejuni. Appl Enviorn Microbiol, 69 6370-6379

101.          Karlyshev, AV., Linton D., Everest P.,  Cawtrhraw S., Newell DG and Wren BW (2004) The Campylobacter jejuni general glycosylation system is important for attachment to human epithelial cells and in the colonization of chicks. Microbiology 150, 1957-64

102.          Gaynor EC., Cawthraw S., Manning G., MacKichan JK., Falkow S and Newell DG (2004) The genome sequenced-variant of Campylobacter jejuni NCTC11168 differs markedly from the original clinical isolate in colonization, gene expression and other virulence-associated phenotypes. J Bacteriol 186(2):503-17.

103.          Harrington CS., Moran L., Ridley AM, Newell DG. And Madden RH (2003) Inter-laboratory evaluation of three flagellin PCR/RFLP methods for typing Campyobacter jejuni and Camp coli: the CAMPYNET experience. J Appl Microbiol. 95, 1321-1333

104.          Randall LP, Ridley AM, Cooles SW, Sharma M, Sayers AR, Pumbwe L, Newell DG, Piddock LJ, Woodward MJ. (2003) Prevalence of multiple antibiotic resistance in 443 Campylobacter spp. Isolated from humans and animals. J Antimicrob Chemother.;52:507-10.

105.          McNally A, Cheasty T, Fearnley C, Dalziel RW, Paiba GA, Manning G. Newell DG.  (2004) Comparison of the biotypes of Yersinia enterocolitica isolated from pigs, cattle and sheep at slaughter and from humans with yersiniosis in Great Britain during 1999-2000. Lett Appl Microbiol.;39:103-8.

106.          MacKichan JK, Gaynor EC, Chang C, Cawthraw S, Newell DG, Miller JF, Falkow S. (2004) The Campylobacter jejuni dccRS two-component system is required for optimal in vivo colonization but is dispensable for in vitro growth. Mol Microbiol. ;54:1269-86.

107.          Newell DG.  (2005) Campylobacter concisus: an emerging pathogen? Eur J Gastroenterol Hepatol;17:1013-4.

108.          Willoughby K, Nettleton PF, Quirie M, Maley MA, Foster G, Toszeghy M, Newell DG. (2005) A multiplex polymerase chain reaction to detect and differentiate Campylobacter fetus subspecies fetus and Campylobacter fetus -species venerealis: use on UK isolates of C. fetus and other Campylobacter spp. J Appl Microbiol. 99:758-66.

109.          Fearnley C, On SL, Kokotovic B, Manning G, Cheasty T, Newell DG. (2005) Application of fluorescent amplified fragment length polymorphism for comparison of human and animal isolates of Yersinia enterocolitica. Appl Environ Microbiol. ;71:4960-5.

110.          Ahmed IH., Ussery DW., Manning G., Newell DG (2005) Comparative genomics in Campylobacter jejuni: An insight into the mechanism of genomic diversity J Genome Science and technology 5, 1-7

111.          Wagenaar J., Jacobs-Reistma and Newell DG (2004) Campylobacter jejuni and Campylobacter coli. In OIE Manual .. 1072-1081

112.          Abuoun M, Manning G, Cawthraw SA, Ridley A, Ahmed IH, Wassenaar TM, Newell DG. Cytolethal distending toxin (CDT)-negative Campylobacter jejuni strains and anti-CDT neutralizing antibodies are induced during human infection but not during colonization in chickens. Infect Immun. 2005 May;73(5):3053-62.

113.          Lee M D; Newell D G 2006 Campylobacter in poultry ; Filling an ecological niche. Avian Diseases 50 1-9

114.           Seigo Usuki, Kyoji Taguchi, Shaun A.Cawthraw, Keiko Shibata, Toshio Ariga, Diane G Newell, and Robert K. Yua*.Human and Chicken Antibodies to Gangliosides Following Infection by Campylobacter jejuni. Experimental Neurology. Exp Neurol. 2006 Jul;200(1):50-5. Epub 2006 Feb 28.

115.  Belcher T, Newell DG. Crossing the boundaries. Vet Rec. 2005 Nov 26;157(22):682-4.

116.  Alfredo Caprioli, Stefano Morabito, Flemming Scheutz, Henrik Chart, Eric Oswald, Maurizio Brigotti, Leo Monnens, Anna Aspan, Roberto La Ragione, Chris Low, and Diane Newell (2006) Pathogenesis of Verocytotoxin/Shiga Toxin–producing Escherichia coli Infection http://www.cdc.gov/ncidod/EID/vol12no08/06-0170.htm

117.          Alan McNally, Tracey Dalton, Roberto M. La Ragione, Georgina Manning, and Diane G. Newell (2006)  Yersinia enterocolitica isolates of differing biotypes from humans and animals are adherent, invasive and persist in macrophages, but differ in cytokine secretion profiles in vitro.
J Med Microbiol;55:1725-34

118.          Alan McNally, Roberto M. La Ragione, Georgina Manning, and Diane G. Newell (2007) An aflagellate mutant Yersinia enterocolitica biotype 1A strain displays altered invasion of epithelial cells, persistence in macrophages, and cytokine secretion profiles in vitro. Microbiology 153 1339-1349

119.  Adkin A, Hartnett E, Jordan L, Newell D, Davison H. 2006 Use of a systematic review to assist the development of Campylobacter control strategies in broilers  J Appl Microbiol. Feb;100(2):306-15

120.          van Bergen MA, Dingle KE., Maiden MJ, Newell DG,  van der Graaf-van Bloois L, van Putten JP, Wagenaar JA. (2005) Clonal nature of Campylobacter fetus as defined by multilocus sequence typing.  Journal of Clinical Microbiology, 2005 Dec;43(12):5888-98.

121.          H. A. Barnes, Mary C. Bagnall, Darren D. Browning, Stuart A. Thompson, Georgina Manning and Diane G. Newell. g-glutamyl transpeptidase has a role in the persistent colonization of the avian gut by Campylobacter jejuni . Microb Pathog. 2007 Nov-Dec;43(5-6):198-207.

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